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About Bio PADLES

Space radiation has affects on biological specimens and samples onboard at the cellular level, including DNA deficits and DNA mutations.

For the life science experiment performed on board the ISS, it is necessary to acquire accurate data of the radiation dose and radiation characteristics as physical environmental parameters for comparing with the physiological indicators in order for quantitatively clarifying the effects of the space radiation exposure to the onboard crews and biological samples. Therefore, Bio PADLES will be installed near biological samples to measure accurately the radiation dose of the samples.

Installation Locations of Bio PADLES

Bio PADLES dosimeters can be installed in various temperature environments (for example, minus 80 degree Celsius in the MELFI refrigerator, and 37 degree Celsius in the Cell Biology Experiment Facility (CBEF)).

Installation Locations of Bio PADLES : Bio PADLES is small-sized, light-weight and unpowered(battery-less) type of dosimeter package so that it can be deployed near the living samples. cell Bio PADLES

Flight Result of Bio PADLES

Bio PADLES dosimeter is launched on a request, from an investigator of a life science experiment selected from JAXA's international life-science program solicitation or the candidate research program of the first review. JAXA performs radiation measurements, data analisys and distribution of biological samples which is important for life science experiments in space.

JAXA's Life Science Experiment Programs (sequentially from 2008)
Abbreviated theme name Experiment Title Principal Investigator Flight Period of PADLES

Rad Gene
Gene expression of p53-regulated Genes in Mammalian Cultured Cells after Exposure to Space Environment Takeo Ohnishi
(Nara Medical University)
Nov. 2008 - March 2009
(134 days)

Detection of Changes in LOH Profile of TK mutants of Human Cultured Cells Fumio Yatagai
Nov. 2008 - March 2009
(134 days)

Dome Gene
Control of cell differentiation and morphogenesis of amphibian culture cells Makoto Asashima
(University of Tokyo)
March 2009 - July 2009
(137 days)

Rad Silk
Integrated assessment of long-term cosmic radiation through biological responses of the silkworm, Bombyx mori, in space Toshiharu Furusawa
(Kyoto Institute of Technology)
Aug. 2009 - Nov 2009
(91 days)

Space Seed
Life cycle of higher plants under microgravity conditions Seiichiro Kamisaka
(University of Toyama)
July 2009 - April 2010
(278 days)

RNA interference and protein phosphorylation in space environment using the nematode Caenorhabditis elegans Atsushi Higashitani
(Tohoku Univesity)
Nov. 2009 - Feb. 2010
(97 days)

Fish Scales
Investigation of the Osteoclastic and Osteoblastic Responses to Microgravity Using Goldfish Scales Nobuo Suzuki
(Kanazawa University)
May 2010
(12 days)

Myo Lab
Cbl-Mediated Protein Ubiquitination Downregulates the Response of Skeletal Muscle Cells to Growth Factors in Space Takeshi Nikawa
(University of Tokushima)
April 2010 - May 2010
(51 days)

Neuro Rad
Biological effects of space radiation and microgravity on mammalian cells Hideyuki Majima
(Kagoshima University)
April 2010 - May 2010
(51 days)
Space Food Changes in Nutrient Contents in Space Food After Long-term Space Flight Akiko Matsumoto
April 2010 - June 2011
(422 days)

SSAF 2010
Space Seeds for Asian Future JAXA Jan. 2011 - June 2011
(130 days)

Regulation by Gravity of Ferulate Formation in Cell Walls of Rice Seedlings Kazuyuki Wakabayashi
(Osaka City University)
May 2010 - March 2011
(299 days)

Hydro Tropi
Hydrotropism and auxin-inducible gene expression in roots grown in microgravity conditions Hideyuki Takahashi
(Tohoku University)
May 2010 - March 2011
(299 days)

Dynamism of Auxin Efflux Facilitators, CsPINs, Responsible for Gravity-regulated Growth and Development in Cucumber Hideyuki Takahashi
(Tohoku University)
Feb. 2011 - June 2011
(96 days)

Effect of microgravity on osteoclasts and the analysis of the gravity sensing system in medaka Akira Kudo
(Tokyo Institute of Technology)
Oct. 2012 - March 2013
(154 days)

Resist Tubule
Mechanisms of Gravity Resistance in Plants Takayuki Hoson
(Osaka City University)
­¡Oct. 2012 - (21 days)
­¢Aug. 2013 - May 2014 (288 days)

Stem Cells
Study on the Effect of Space Environment to Embryonic Stem Cells to Their Development (Stem Cells) Takashi Morita
(Osaka City University)
­¡March 2013 - July 2017 (1584 days)
­¢April 2014 - Oct. 2014 (190 days)
­£Sep. 2014 - Feb. 2015 (142 days)
­¤Jan. 2015 - May 2016 (487 days)
­¥Aug. 2015 - May 2016 (266 days)
­¦April 2016 - July 2017 (450 days)
­§July 2016 - July 2017 (350 days)

Space Pup
Effect of space environment on mammalian reproduction (Space Pup experiment) Teruhiko Wakayama
(Yamanashi University)
­¡Aug. 2013 - May 2014 (1736 days)
­¢Aug. 2013 - May 2016 (1012 days)
­£June 2017 - May 2018 (335 days)
­¤April 2018 - Jan. 2019 (286 days)

Cell Mechanosensing
Physiological relevance of tension fluctuations in plasma membrane (Cell Mechanosensing experiment) Masahiro Sokabe
(Nagoya University)
­¡April 2014 - May 2014 (30 days)
­¢Sep. 2014 - Oct. 2014 (34 days)

Epigenetics in spaceflown C. elegans (Epigenetics) Higashitani Atsushi
(Tohoku University)
Jan. 2015 - Feb. 2015 (30 days)

Space Environmental Testing of Lightweight and High Precision Carbon Composite Mirrors Nisihori Toshiyuki
Aug. 2015 -
­¡March 2017 (578 days)
­¢Aug. 2018 (1080 days)

Embryo Rad
Life time heritable effect of space radiation on mouse germ cells and embryos preserved for a long term in ISS Shizuko Kakinuma
(National Institute of Radiological Sciences)
April 2015 - May 2016 (393 days)

Space Aging
Study of the effects of space flight on the aging of C. elegans (Space Aging) Yuko Honda
(Tokyo Metropolitan Institute of Gerontology)
April 2015 - May 2015 (36 days)

Mouse Epigenetics
Transcriptome analysis and germ cell development analysis of mice in the space (Mouse Epigenetics) Satoru Takahashi
(Tsukuba University)
July 2016 - Aug. 2016 (35 days)

Position Sensitive Tissue Equivalent Proportional Chamber (PS TEPC) Shinichi Sasaki
(Radiation Science Center, KEK)
­¡Dec. 2016 - June 2017 (206 days)
­¢June 2017 - Jan. 2018 (224 days)

Multi Omics Mouse
Multi Omics Analysis of Human Microbial Metabolic Cross talk in the Space Ecosystem Hiroshi Ohno
Aug. 2017 - Sep. 2017 (33 days)

Zebrafish Muscles 2
Effects of the gravity on maintenance of muscle mass in zebrafish (Zebrafish Muscle) Atsuko Sehawa
(Kyoto University)
Dec. 2017 - Jan. 2018 (29 days)

Mouse Stress Defense
Role of Environmental Stress responsive Transcription Factor Nrf2 in Space Stress Masayuki Yamamoto
(Tohoku University)
April 2018 - May 2018 (31

Mouse Stress Defense 2
Characterization of blood vessel gateway formation and molecule expression at dorsal vessels of spinal cords by gravity stimulation Masaaki Murakami
(Hokkaido University)
May 2019 - June 2019 (31 days)

Smart Optical Fibres for Passive Dosimetry in Space Fathinul Fikri, Noramaliza & Nizam
(Universiti Putra Malaysia)
May 2019 - Jan. 2020 (248 days)

Mouse Habitat Unit 5
JAXA Mouse Mission 5 (MHU-5) Dai Shiba
March 2020 - April 2020 (32 days)