About Bio PADLES
Space radiation has affects on biological specimens and samples onboard at the cellular level, including DNA deficits and DNA mutations.
For the life science experiment performed on board the ISS, it is necessary to acquire accurate data of the radiation dose and radiation characteristics as physical environmental parameters for comparing with the physiological indicators in order for quantitatively clarifying the effects of the space radiation exposure to the onboard crews and biological samples. Therefore, Bio PADLES will be installed near biological samples to measure accurately the radiation dose of the samples.
Installation Locations of Bio PADLES
Bio PADLES dosimeters can be installed in various temperature environments (for example, minus 80 degree Celsius in the MELFI refrigerator, and 37 degree Celsius in the Cell Biology Experiment Facility (CBEF)).
Flight Result of Bio PADLES
Bio PADLES dosimeter is launched on a request, from an investigator of a life science experiment selected from JAXA's international life-science program solicitation or the candidate research program of the first review. JAXA performs radiation measurements, data analisys and distribution of biological samples which is important for life science experiments in space.
| Abbreviated theme name | Experiment Title | Principal Investigator | Flight Period of PADLES |
|---|---|---|---|
 Rad Gene |
Gene expression of p53-regulated Genes in Mammalian Cultured Cells after Exposure to Space Environment | OHNISHI Takeo (Nara Medical University) |
Nov. 2008 - March 2009 (134 days) |
 LOH |
Detection of Changes in LOH Profile of TK mutants of Human Cultured Cells | YATAGAI Fumio (RIKEN) |
Nov. 2008 - March 2009 (134 days) |
 Dome Gene |
Control of cell differentiation and morphogenesis of amphibian culture cells | ASASHIMA Makoto (University of Tokyo) |
March 2009 - July 2009 (137 days) |
 Rad Silk |
Integrated assessment of long-term cosmic radiation through biological responses of the silkworm, Bombyx mori, in space | FURUSAWA Toshiharu (Kyoto Institute of Technology) |
Aug. 2009 - Nov 2009 (91 days) |
 Space Seed |
Life cycle of higher plants under microgravity conditions | KAMISAKA Seiichiro (University of Toyama) |
July 2009 - April 2010 (278 days) |
 CERISE |
RNA interference and protein phosphorylation in space environment using the nematode Caenorhabditis elegans | HIGASHITANI Atsushi (Tohoku Univesity) |
Nov. 2009 - Feb. 2010 (97 days) |
 Fish Scales |
Investigation of the Osteoclastic and Osteoblastic Responses to Microgravity Using Goldfish Scales | SUZUKI Nobuo (Kanazawa University) |
May 2010 (12 days) |
 Myo Lab |
Cbl-Mediated Protein Ubiquitination Downregulates the Response of Skeletal Muscle Cells to Growth Factors in Space | NIKAWA Takeshi (University of Tokushima) |
April 2010 - May 2010 (51 days) |
 Neuro Rad |
Biological effects of space radiation and microgravity on mammalian cells | MAJIMA Hideyuki (Kagoshima University) |
April 2010 - May 2010 (51 days) |
| Space Food | Changes in Nutrient Contents in Space Food After Long-term Space Flight | MATSUMOTO Akiko JAXA |
April 2010 - June 2011 (422 days) |
 SSAF 2010 |
Space Seeds for Asian Future | JAXA | Jan. 2011 - June 2011 (130 days) |
 Ferulate |
Regulation by Gravity of Ferulate Formation in Cell Walls of Rice Seedlings | WAKABAYASHI Kazuyuki (Osaka City University) |
May 2010 - March 2011 (299 days) |
 Hydro Tropi |
Hydrotropism and auxin-inducible gene expression in roots grown in microgravity conditions | TAKAHASHI Hideyuki (Tohoku University) |
May 2010 - March 2011 (299 days) |
|
CsPINS |
Dynamism of Auxin Efflux Facilitators, CsPINs, Responsible for Gravity-regulated Growth and Development in Cucumber | TAKAHASHI Hideyuki (Tohoku University) |
Feb. 2011 - June 2011 (96 days) |
 MEDAKA OSTEOCLAST |
Effect of microgravity on osteoclasts and the analysis of the gravity sensing system in medaka | KUDO Akira (Tokyo Institute of Technology) |
Oct. 2012 - March 2013 (154 days) |
 Resist Tubule |
Mechanisms of Gravity Resistance in Plants | HOSON Takayuki (Osaka City University) |
①Oct. 2012 - (21 days) ②Aug. 2013 - May 2014 (288 days) |
 Stem Cells |
Study on the Effect of Space Environment to Embryonic Stem Cells to Their Development (Stem Cells) | MORITA Takashi (Osaka City University) |
①March 2013 - July 2017 (1584 days) ②April 2014 - Oct. 2014 (190 days) ③Sep. 2014 - Feb. 2015 (142 days) ④Jan. 2015 - May 2016 (487 days) ⑤Aug. 2015 - May 2016 (266 days) ⑥April 2016 - July 2017 (450 days) ⑦July 2016 - July 2017 (350 days) |
 Space Pup |
Effect of space environment on mammalian reproduction (Space Pup experiment) | WAKAYAMA Teruhiko (Yamanashi University) |
①Aug. 2013 - May 2014 (1736 days) ②Aug. 2013 - May 2016 (1012 days) ③June 2017 - May 2018 (335 days) ④April 2018 - Jan. 2019 (286 days) |
 Cell Mechanosensing |
Physiological relevance of tension fluctuations in plasma membrane (Cell Mechanosensing experiment) | SOKABE Masahiro (Nagoya University) |
①April 2014 - May 2014 (30 days) ②Sep. 2014 - Oct. 2014 (34 days) |
 Epigenetics |
Epigenetics in spaceflown C. elegans (Epigenetics) | HIGASHITANI Atsushi (Tohoku University) |
Jan. 2015 - Feb. 2015 (30 days) |
 CAGOME |
Space Environmental Testing of Lightweight and High Precision Carbon Composite Mirrors | NISIHORI Toshiyuki (JAXA) |
Aug. 2015 - ①March 2017 (578 days) ②Aug. 2018 (1080 days) |
 Embryo Rad |
Life time heritable effect of space radiation on mouse germ cells and embryos preserved for a long term in ISS | KAKINUMA Shizuko (National Institute of Radiological Sciences) |
April 2015 - May 2016 (393 days) |
 Space Aging |
Study of the effects of space flight on the aging of C. elegans (Space Aging) | HONDA Yuko (Tokyo Metropolitan Institute of Gerontology) |
April 2015 - May 2015 (36 days) |
 Mouse Epigenetics |
Transcriptome analysis and germ cell development analysis of mice in the space (Mouse Epigenetics) | TAKAHASHI Satoru (Tsukuba University) |
July 2016 - Aug. 2016 (35 days) |
 PS TEPC |
Position Sensitive Tissue Equivalent Proportional Chamber (PS TEPC) | SASAKI Shinichi (Radiation Science Center, KEK) |
①Dec. 2016 - June 2017 (206 days) ②June 2017 - Jan. 2018 (224 days) |
 Multi Omics Mouse |
Multi Omics Analysis of Human Microbial Metabolic Cross talk in the Space Ecosystem | OHNO Hiroshi (RIKEN) |
Aug. 2017 - Sep. 2017 (33 days) |
 Zebrafish Muscles 2 |
Effects of the gravity on maintenance of muscle mass in zebrafish (Zebrafish Muscle) | SEHAWA Atsuko (Kyoto University) |
Dec. 2017 - Jan. 2018 (29 days) |
 Mouse Stress Defense |
Role of Environmental Stress responsive Transcription Factor Nrf2 in Space Stress | YAMAMOTO Masayuki (Tohoku University) |
April 2018 - May 2018 (31 |
 Mouse Stress Defense 2 |
Characterization of blood vessel gateway formation and molecule expression at dorsal vessels of spinal cords by gravity stimulation | MURAKAMI Masaaki (Hokkaido University) |
May 2019 - June 2019 (31 days) |
 SOFPADS |
Smart Optical Fibres for Passive Dosimetry in Space | Fathinul Fikri, Noramaliza & Nizam (Universiti Putra Malaysia) |
May 2019 - Jan. 2020 (248 days) |
 Mouse Habitat Unit 5 |
JAXA Mouse Mission 5 (MHU-5) | SHIBA Dai (JAXA) |
March 2020 - April 2020 (32 days) |
 Space Embryo |
Early Mammalian Embryogenesis Under Microgravity in Space | Teruhiko Wakayama (Yamanashi University) |
2021- |
 Sperm Stem Cells |
Effect of space environment on fertility of spermatogonial stem cells | SHINOHARA Takeshi (KYOTO UNIVERSITY) |
2022- |
 Plant UV-B |
Study on plant responses against the stresses of microgravity and high ultraviolet ray in space | HIDEMA Jun (Tohoku University) |
TBD |